Renovascular hypertension pathology

Renovascular hypertension due to ischemia caused renin - angiotensin - aldosterone axis and the activation. The renal perfusion due to a decrease in the release of renin, renin angiotensin reasons prompted into angiotensin Ⅰ, angiotensin Ⅰ the conversion of angiotensin-converting-enzyme angiotensin Ⅱ. Angiotensin Ⅱ is a strong Vasoconstrictor, angiotensin Ⅱ (A Ⅱ) can also stimulate the adrenal gland secretion of aldosterone, which have sodium retention.
Renal artery occlusive disease incidence can be unilateral or bilateral, or occurred in patients with kidney alone, because different types of renal vascular hypertension pathophysiology not the same. In the renal mode (renal, a clamp-type kidney), renal ischemia Shuinazhuliu lead to the release of renin, but normal contralateral kidney will pressure sodium row of the diuretic, so that patients actually negative sodium balance, has further increased the renin release. Kidney in a single mode (single kidney, renal clamp-type), not the impact of the contralateral kidney, thereby preventing the loss of sodium, extracellular fluid volume increase in the number of blood renin inhibition activity, such patients with high blood pressure main is caused by excessive fluid. Patients with renal artery stenosis with a similar situation.

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