Insulin resistance is also cause hypertension

Insulin resistance is obesity and hypertension risk factors one by oral glucose tolerance test and insulin release test of the indirect indicators of insulin sensitivity compared with EICT law, about 10 ~ 20% of the patients missed in the conditions do not EICT units available insulin area under the curve, fasting glucose and fasting insulin product countdown, as two better insulin sensitivity of the indirect indicators of renal vascular hypertension does not exist obvious insulin resistance, the insulin resistance that is the primary in hypertension, and blood pressure secondary to increased insulin resistance in patients with essential hypertension and abnormal metabolism of the other closely related to the merger of insulin resistance in patients with essential hypertension incidence of salt sensitivity, blood lipids and blood uric acid levels than those without insulin resistance in patients with hypertension, that insulin resistance may be the root cause of the abnormal metabolism.

The study is the first demonstration of insulin resistance in patients with essential hypertension and heart, brain and kidney damage in the three organs process, that is, without insulin resistance in hypertension → hypertensive patients with insulin resistance Ⅱ → hypertensive patients with type 2 diabetes. The study also found that perindopril and amlodipine in addition to relief, but also improve insulin sensitivity, and no effect of nifedipine.

The etiology and pathology of hypertension

The etiology and pathogenesis of the disease has not yet fully appreciate principle. Through years of observational study, compared recognized with the following factors: (1) Age: Statistics found over 40 years of age suffering from hypertension and more than 40 people under the age of 3.5 times (2) job and the Environment: Where a high degree of attention concentrated, excessive tension in the mental work or work environment are susceptible to the irritation of hypertension; (3) Family genetic: Statistics found that 50 percent of hypertension patients have family history, it is felt that the genetic and (4) too much salt: Some people carried out of a trial, more than five grams of salt a day compared with less than 5 grams of the large proportion of hypertension (5) Obesity: overweight, hypertension than the normal high incidence of 2-6 times (6) Smoking: The experiment proved that the smoke of nicotine on the role of vascular endothelial injury there can lead to atherosclerosis, hypertension occurred.
Blood pressure and cardiac ejection peripheral resistance the result of the interaction, the two rely on each other to maintain balance if the blood pressure for some factors that balance will be destroyed in high blood pressure, such as the movement of the central nervous central vascular dysfunction, resulting in vascular systolic and diastolic dysfunction, and also because of renin - excessive secretion of angiotensin can make systemic arterial spasm small, the long, small arterial oxygen vacancy occurred Hyalinized, fibrous tissue and endometrial fibroelastosis, a small artery sclerosis, advanced by ischemia and hypoxia can be an important organ dysfunction occurred.

The biochemical mechanism of genetic hypertension

The biochemical mechanism of genetic hypertension

The current biochemical research results support the following Hypertension is a genetic disease:

(1) transmembrane cation transporter defect: blood pressure in patients with essential hypertension and “normal” children of sodium, potassium ion membrane transporter inhibition, leading to intracellular sodium and calcium ion concentration increased, from the vascular smooth muscle contraction, was increased.

(2) Sympathetic media metabolic deficiencies: the plasma of patients with essential hypertension infants phenol-amine B hydroxylase and dopamine content of genetic activity increased, leading to cardiac hypertrophy, the vascular smooth muscle contraction.

(3) renal function and endocrine dysfunction: patients with essential hypertension reduced glomerular filtration rate, renal vascular hormone on the vasoconstrictor response to increased reserves decreased renal function, such as sensitive to salt boost.

(4) abnormal arterial smooth muscle calcium pool: cells in patients with essential hypertension increased calcium channel, resulting in calcium flow increased intracellular calcium ion concentration increased, from the vascular smooth muscle contraction, increased peripheral resistance, elevated blood pressure.

Discover new mechanism of hypertension

Technical University of Munich, Germany, Professor Hoffman on March 13 announced to the media, he led a research team had found a can of protein vascular muscle relaxation TRAG-Prot ein. The discovery will allow people to further understand the pathogenesis of hypertension, and find a treatment for cardiovascular diseases laid the foundation for new methods.
Professor Hoffman explained that hypertension was mainly due to the vascular wall excessive calcium in the muscle cells, leading to hardening caused by the vascular wall. The team found that this protein can prevent calcium in the blood vessel wall cells in free. But if such obstacles in the function of proteins, vascular relaxation of the wall will lose a result of high blood pressure, which led to coronary heart disease. Pathogenesis of Hypertension This applies to most types of hypertension, renal artery stenosis only causes such as disease except for a small number of hypertension. Therefore, as long as control of this protein can be effective in preventing hypertension.
Professor Hoffman said, the study results published in the United Kingdom recently published in the “Nature” magazine. But this will be found for it will take several years of the time, which must be a lot of animal experiments.

Do not hurt the renal hypertension

Hypertension is a common disease widely popular, if not effectively controlled, will be hurt a lot of important organs, and cause serious heart, brain and kidney complications. Many patients with hypertension for cardiovascular and cerebrovascular complications very seriously, but he has overlooked the kidney complications. Contrary to the hypertension caused kidney damage, not only can cause abnormal urine test, progress will be serious uremia. The data show that in recent years, due to hypertension and kidney damage caused chronic renal insufficiency enter the number of patients showed an increasing trend, about 18 percent of patients with hypertension eventually renal insufficiency. With the same level of comparison with essential hypertension, chronic renal disease on the basis of the merger of the complications of hypertension caused more harm kidneys and can turn and accelerate chronic kidney disease (especially chronic glomerular diseases) the progress of a vicious cycle.

Beginnings blood pressure control is the key

Found a kidney damage and how to stop? More stringent control of blood pressure is the key. When kidney damage, proteinuria, the ideal target for the buck 130/80 mmHg. Urinary protein more than 1 g per 24 hours should be more stringent, blood pressure must be controlled within 125/75 mmHg. Among them, lower systolic blood pressure is more important. To the target level of blood pressure, it is to prevent kidney damage the fundamental way.

Hypertension with kidney damage, and should be chosen with antihypertensive Baoshen dual role of the drug. Preferred angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor antagonist Ⅱ (ARB), as both can be improved glomerular “three high” state, the protection of the kidney. Calcium channel blockers are commonly used antihypertensive agents, because of its antihypertensive effect of strong effect from salt intake impact ACEI or ARB Therefore, the antihypertensive effects of poor, often takes a combination of the drug. In addition, other commonly used antihypertensive drugs, such as diuretics, β-blockers and α receptor blockers, have blood pressure-dependent renal protective effect, the use of these drugs for hypertension, as long as the blood pressure to goal value can postpone the renal damage.

Pay attention to the process of drug monitoring of blood pressure and adverse reactions, such as a blood pressure drugs can not target, then combined. If the medication after cough, edema, rashes, and other anomalies, timely medical treatment.

Preventive health care is very important to improve lifestyle

Reasonable diet, moderate exercise, limit alcohol, smoking cessation in patients with hypertension is the basic principle of life. Among them, for the coexistence of renal dysfunction in patients with hypertension, should be low-protein diet, that is, per kg body weight per day 0.8 g protein, this can reduce kidney disease caused by the abnormal blood flow, significantly delay the progress of kidney disease. Food choices should be based on high quality protein, such as milk, eggs, meat and other animal protein, such as reducing soybean plant protein intake.

The hunger will increase the decomposition of the body metabolism, increase the formation of acidic product, low-protein diet control, we must ensure that enough of the calorie intake. Every day should reach 250-300 grams of carbohydrates, fats food is not more than 50 grams.

Salt hypertensive patients be limited. The chemical structure of salt is sodium chloride, excessive salt intake, the body will be a higher level of sodium ions. Sodium retention of the water, extracellular fluid, including blood volume thus increased, and the results may lead to hypertension. Taking antihypertensive agents, diuretics at the same time, such as to control salt intake, and often can have a multiplier effect.

According to the standard limit salt elevated levels of blood pressure vary, the general control advocates in the following six grams a day; strict, may be limited to 3-5 grams; more strictly, or even daily to 1-2 grams. It should also be noted that the 5 milliliters of sodium soy sauce volume of 1 gram of salt, salt restriction in the circumstances, we must pay attention to reduce the intake of soy sauce. In addition, such as Xianru, and pickles, salted fish, ham, Canadian and other alkali or Fajiaofen made pasta, containing sodium and more food should be restricted.

Astragalus treatment of hypertension

Astragalus most appropriate treatment of blood deficiency in patients with hypertension, and such patients veins see weakness, shortness of breath fatigue, dizziness and the strong, Yaoxisuanruan, hand, foot and heart fever, head Shibuya tinnitus, rather than high diastolic blood pressure drop, symptoms lot.

Astragalus, also known as the policy and made Dai, accepting the grass, 100 wood, Astragalus membranaceus. According to the “Compendium of Materia Medica” record: Astragalus味甘of temperature, Rubi, Lung, a table-Air and Water, nourishing Shengji toxicity of reactive care. However, modern pharmacology scientists in the study also found that Astragalus treatment of hypertension, significant efficacy and non-toxic.

Astragalus most appropriate treatment of blood deficiency in patients with hypertension, and such patients veins see weakness, shortness of breath fatigue, dizziness and the strong, Yaoxisuanruan, hand, foot and heart fever, head Shibuya tinnitus, rather than high diastolic blood pressure drop, symptoms lot.

Clinical application, and the Air Ziyin soup often used in conjunction with the first intake of 30 grams of Astragalus, Ligustrum lucidum 25 g, 25 g Loranthaceae, Achyranthes 10 grams, five grams Zexie, Koto 20 g, 30 g oysters, but also According to the permit and permit modified. On this side of Western medicine after oral administration in normal systolic blood pressure control, but always in the diastolic blood pressure above 100 mm Hg drop in patients not, the effect is particularly notable.

Pharmaceutical experts in China in the study found: Astragalus is a two-way role in regulation of blood pressure, clinical usage hours or blood pressure, lower blood pressure, Astragalus reuse. Therefore, the treatment of hypertension, the amount must be Astragalus more than 30 grams, Qi and blood stasis can be the appropriate amount of patients. Where Qiyinliangxu Syndrome hypertension, astragalus and associate Ziyin Bushen medicine, should be slightly larger than the amount of Astragalus Ziyin drugs. Patients with coronary heart disease and hypertension, astragalus and Blood Circulation drug association, will Astragalus times the amount of drugs Blood Circulation. Hypertension and neck pain, Astragalus should be associating with puerarin, with a 2:1 ratio. Hypertensive patients with glomerulonephritis edema, and the defense has been available Astragalus compatibility. Hypertension and diabetes should be elected Astragalus associate with the yam, so compatibility medication can once and for all, improve the curative effect.

Astragalus Chinese medicine theory believes that the role of different processing methods vary, Health Astragalus take form, Shengji. Sunburn Astragalus meeting offal, but true high fever should Jiyong heat.

This recipe, please use under the guidance of doctors.

Honey resisted the treatment of hypertension

Clinical application of modern medicine that, honey can promote digestion and absorption, increase appetite, sedation sedative-hypnotic, increase body resistance, the promotion of the growth and development of infants and young children have a positive role. Governance hypertension: 100 grams of honey, black sesame 75 grams, the first black sesame steamed chopped Runi keep mixing honey with a warm dry, taking 2 hours daily.

Blood pressure unstable governance: sooner or later the daily drink pure honey 1 cup water, will become normal blood pressure, patients can eliminate the imbalance of blood pressure problems.

Adults calcium can lower blood pressure

The researchers recommended in patients with hypertension is not only low-salt diet should also be high calcium diet. Adults about 1200-1500 mg of calcium per day, approximately 5 cups of milk, if not fixed to obtain from natural food in adequate calcium, calcium is taking effective method. Adults need calcium to prevent osteoporosis view has been accepted by the people, Xi’an Medical’s research shows that calcium can lower blood pressure.

According to the Xi’an Medical since the beginning of 1987, the average Chinese person excessive salt intake and hypertension, 300 patients with hypertension for two consecutive years after the discovery of high-calcium diet, the condition has improved, the average can lower blood pressure about 4 mmHg. And not high calcium diet and the control group, blood pressure rose by an average of 2 mmHg.

The researchers recommended in patients with hypertension is not only low-salt diet should also be high calcium diet. Adults about 1200-1500 mg of calcium per day, approximately 5 cups of milk, if not fixed to obtain from natural food in adequate calcium, calcium is taking effective method. Lowering blood pressure and calcium supplement should be more exercise, more than the sun, vitamin D increase.

Metabolic hypertension treatment

As obesity, abnormal glucose and lipid abnormalities atherosclerosis are an independent risk factor, and close to essential hypertension, regular interaction. Therefore, in treatment should be considered. If the antihypertensive treatment can not only improve the accompanying metabolic disorders, contrary to some antihypertensive agents will increase metabolic disorder, resulting in patients with symptoms exacerbated, repeated blood pressure fluctuations can not stabilize. Essential hypertension, if combined with glucose or lipid abnormalities, clinical called “metabolic hypertension.” Its incidence in patients with essential hypertension in as high as 60% -80%. As obesity, abnormal glucose and lipid abnormalities atherosclerosis are an independent risk factor, and close to essential hypertension, regular interaction. Therefore, in treatment should be considered. If the antihypertensive treatment can not only improve the accompanying metabolic disorders, contrary to some antihypertensive agents will increase metabolic disorder, resulting in patients with symptoms exacerbated, repeated blood pressure fluctuations can not stabilize.

Well, metabolism hypertension treatment should pay attention to?

On the metabolism of hypertension should first consider non-drug therapy. Adverse changes in living habits, smoking cessation, control of alcohol, diet, proper physical exercise, which have significantly improved insulin resistance, reducing atherosclerosis, reduced the risk of cardiovascular disease. Antihypertensive treatment needs to be considered when blood glucose, blood lipid abnormalities, as diuretics and β-blockers to reduce the dosage.

The obese patients should choose fat-soluble drugs more effective, such as fosinopril, ramipril, nimodipine and equality.

If insulin resistance, the option of angiotensin-converting enzyme inhibitors or angiotensin receptor antagonist Ⅱ, such as Lotensin, Lo Shatan, etc.. Dihydrochloride can use non-pyridine calcium antagonists, such as nitrendipine, and so on, or use long-term dihydrochloride pyridine calcium antagonists, such as Saint-equality. Furthermore, the selection has improved with insulin resistance in hypoglycemic agents, such as metformin, such as hypoglycemic Ling. If high triglyceride, and the option of Connaught McMillan; high low-density lipoprotein cholesterol may choose to use Simvastatin, Effect of lovastatin. Xuezhikang option, zhinbiticose and other proprietary Chinese medicines.

Therefore, it should be stressed that the diagnosis and treatment of cardiovascular disease, hypertension metabolism should be vigilant, especially when the buck ineffective, it is necessary to check and the blood glucose, blood lipids, as soon as possible in order to clear diagnosis, and correctly guide treatment.

Treating hypertension celery

Celery with antihypertensive effect from the celery in the separation of an alkaline elements, Weitianjingzuoyong; Acceptance to celery root, washed with cold water, Jiashi, by adding contour honey or syrup. Dry-Qin, also known as celery, carvone, such as Boqin. In addition to good-mouth food, but also medicinal effects.

Celery with antihypertensive effect from the celery in the separation of an alkaline elements, Weitianjingzuoyong; Acceptance to celery root, washed with cold water, Jiashi, by adding contour honey or syrup.

Served three times a day, each 40 ml (clothes heating), the cholesterol-lowering effect of the treatment of hypertension quite good; the primary, pregnancy and menopause hypertension are valid. 10 with celery root, washed Daolan, increase jujube 10, decoction, served daily at 2, 15-19-20 days for a course of treatment. Treatment of hypertension, coronary heart disease, such as serum cholesterol over 200 mg per cent or more, have better efficacy. To the best of fresh celery root, not fresh for the second. Celery, the Health and Fire scabies were not served. There is a long L. Maoqin, not the edible.