ITP symptoms and treatment

ITP is a common hemorrhagic disease, causes complex, it is also more difficult for the capital Medical University School of Chinese Medicine of Beijing Medical subsidiary Gulou Chinese medicine hospitals Hall Primary ITP is a professional specialist in primary ITP treatment and research institutions, many of four treatment invalid ITP patients find here the hope of rehabilitation.

ITP is characterized by a significant reduction of platelet, with skin mucosa Purpura, who may have other serious bleeding sites such as nose bleeding, bleeding gums, women’s menstrual of excessive or serious vomit blood, hemoptysis, blood in the stool, and other symptoms Niaoxue , With intracranial hemorrhage is the cause of the disease died. Henoch-Schonlein purpura is characterized by skin limbs scattered spots or affect general, patients with severe joint pain or abdominal pain, blood in the stool, vomit blood, such as the collapse of serious cases can be developed for Purpura nephritis. ITP is divided into two categories of primary and secondary. Primary ITP is an autoimmune syndrome, is a common hemorrhagic disease. Is characterized by blood circulation in the anti-platelet antibodies, so that excessive platelet destruction caused purpura, and giant cells in the bone marrow of normal or more of the naive. Clinical acute and chronic can be divided into two, both pathogenesis and performance have significantly different.

Acute multi-for children under 10 years of age, no gender differences. More in winter and spring disease, before the disease has infected more than history, more respiratory infections, rubella, measles, chickenpox most; may also vaccination, infection and the incubation period purpura in more than one to three weeks. Adult acute-rare, often drug-related, than children with serious illness. Jizhou onset, fever.

Mainly for skin and mucous membrane bleeding, often more serious, skin was bleeding from the size of stasis, the uneven distribution to more limbs. Mucosa have epistaxis bleeding, bleeding gums, tongue oral mucosa Xuepao. Common digestive, urinary tract bleeding, bleeding under the eye of film, a small number of retinal hemorrhage. Common spinal cord or intracranial hemorrhage, can cause lower limb paralysis or performance of intracranial hypertension, can be life-threatening.

Chronic more common type of primary ITP of 80 percent, more than 10 to 40 years old, men and women for three to four times. Hidden passage of onset. Patients can have persistent or recurrent bleeding, and some local performance for the bleeding tendency, such as repeated epistaxis or menorrhagia. Stasis points and Yuban can occur in any part of the skin and mucous membrane, but the limbs to more remote. Will have gastrointestinal and urinary tract hemorrhage. Trauma may also appear deep hematoma. Intracranial hemorrhage rare, but in the event of acute attacks occur. Breathing deep in the spleen, even reach.

Primary ITP the etiology and pathogenesis, has not yet been clarified. And that is a more immune-related diseases.

At present western medicine treatment of ITP and allergic purpura is the preferred drug hormones, taken after the platelet generally increased, but the side effects of hormone very great increase in platelets at the same time will add many new diseases, such as concentric Obesity, hypertension, diabetes, osteoporosis, and hormone reduction, the platelet will be reduced, after stopping attacks will be repeated. Splenectomy risk of surgery, patients themselves difficult to accept. Spleen is the body’s immune organ, the splenectomy after the immunocompromised patients, easily lead to serious infections, to patients with physical and mental brought great suffering, the splenectomy after the relapse rate in 58 percent. Is there a method not only increased platelet, disease control, but also alternative hormone, the body will not produce side effects » National autoimmune disease experts, doctors Beijing Gulou Chinese medicine hospitals in Beijing Museum of primary ITP specialist founder Professor Jin Chu-lan mainly of the Group Based on years of clinical experience, with great concentration study, the use of early-model of the first principle of immunity The establishment of the integrity of the Chinese concept of immunology. The results stated ITP the pathogenesis.

Professor Jin Chu-lan was born in 1952 in Fujian She Nationality Chinese family, graduated from the Jiangxi College of Traditional Chinese Medicine. In the autoimmune disease treatment and research for nearly 30 years, keen to medicine, industry expertise in ground handling. Is the capital of the Gulou Chinese medicine hospitals Medical University (Beijing Medical Museum) experts, and as lupus erythematosus, director of the Institute of Dalian, Weihai bimodal director of the Institute of Chinese Medicine, director of the Chinese Society for Chinese Medicine, Chinese Society for Chinese Medicine Council of AIDS , Vice chairman of the China International Association for autoimmune diseases to health care professionals, chairman of the Committee, “capital of medicine” Magazine Editors.

Professor Jin Chu-lan, ITP is the pathogenesis of pulp, the onset of incentives (such incentives can come from both inside and outside) the stimulation, Ki-hang of Fu’s “pulp” to respond and produce a The whole concept of the viscera model to meet the changes. This pattern projector in a holistic manner to various body organs viscera. Rapidly, and form a new body, and when this status and further strengthen the “pulp” to stimulate the formation of a vicious circle. This vicious cycle of continued role in the body, so that pathological changes in the body, which showed systemic symptoms, skin Yuban or stasis, epistaxis, gingival bleeding, urine, menorrhagia, blood in the stool, cerebral hemorrhage, but also performance To the symptoms of anemia. This is what we said ITP.

Children allergic purpura

Henoch-Schonlein purpura is capillary inflammation as the major diseases of the allergic diseases, the most common involving the skin, followed by the gastrointestinal tract, bone and kidney, more radical onset, the symptoms varied. Occurred in children over 3 years of age, especially more common in school-age children, male about 2 times the incidence in women. Prior to the onset of 1-3 weeks often have the upper respiratory tract infection, the incidence than spring and autumn. In addition to involvement outside the kidney hormone treatment, such as better response. In the course more than a month or so, sometimes extended, but the high relapse rate, about 30 percent of patients tend to relapse.

[Symptoms of disease]

1. Purpura skin: more common in lower limbs, buttocks and upper times, symmetry distribution, in batches, the pressure does not fade, fat red or red, with vessels and nerves edema. 2. Abdominal pain: for Duntong, paroxysmal pain or cramps, location uncertain, abdominal soft, with vomiting and bloody. 3. Joint pain: redness and activities with obstacles, mainly tired knee, ankle, wrist and elbow, may be single or multiple, can walk. 4. Kidney symptoms: hematuria, edema and hypertension. Can be expressed as nephritis, or kidney-like comprehensive change, even can be developed for acute and chronic failure.

Vasculitis allergic purpura

Overview

Henoch-Schonlein purpura is due to systemic vascular inflammation caused by blood or plasma components into the skin, mucous membrane and serous arising under the skin for the performance of stasis, Yuban, joint pain, abdominal pain and kidney damage syndrome. The main incentives are bacteria, viruses, parasitic infections, with food, medicine and other allergens also a former relationship. The disease can be in any age group incidence to children and adolescents Most of the highest incidence of the spring. The removal of incentives and appropriate medical treatment, the cure rate was higher. But the condition easy to relapse, abdominal and renal disease patients with more severe, such as with complications or complications can be life-threatening. In dealing with emphasis on early diagnosis and early treatment will help improve the cure rate.

[Symptoms of disease]

1. Fever, headache, fatigue, irritable children Changbiaoxianwei 2. Needle or soybeans reach the size of stasis, Yuban; weight, blood cells, necrosis and shallow ulcers, 3. Occur in both lower extremities, particularly To calf stretch of the main 4. Joints of joint swelling and pain can occur, the rash often distributed in the joints around 5. Gastrointestinal multi-with vomiting, abdominal pain and blood in the stool, 6. Kidney-can occur hematuria, proteinuria, the Of urine.

[Diagnosis]

1. Recurring lower extremities to the main distribution reach Purpura, 2. Accompanied by abdominal pain, joint pain or hematuria, such as proteinuria, 3. Platelet count and normal clotting time, ESR fast, 4. Eosinophil direct Count increased, 5. Pathological examination prompted the WBC small artery fragmentation vasculitis, 6. IgA specific immune examination increased.

Other special type of leukemia outlined

1. Sarcoma lymphatic leukemia means the lymph sarcoma occurred in the course of extensive bone marrow transfer. Children period lymphoma about 30% of acute lymphoblastic leukemia, the incidence rate is higher than adults. Patients often have lower jaw, neck, mediastinum, such as swollen lymph nodes, and hepatosplenomegaly. The performance of a lymphoma, have ALL the blood and bone marrow examination findings. ALL often by the general treatment, but the prognosis worse than ALL, easy to relapse.

2. Green means of leukemia and other sites in the course of a bone tumor disease, for the performance of local nodular or massive uplift. More common in orbital bone, temporal bone, nose, sternum, ribs and pelvic bones and other flat bone periosteum, the entire body of the lymph nodes, liver, spleen, kidney, lung, muscle, breast and the dura mater, other offal are also violations . And the appearance of tumor biopsy showed Green Green, Gu Ming of the green. Slice contact with air and sunshine can quickly disappear after the green, after hydrogen peroxide treatment of sodium or green can now resume. More common in acute myeloid leukemia, very few mergers in other types of leukemia. In addition to the general symptoms of leukemia, according to different sites involved, there can be corresponding symptoms. If violations can cause eye protruding eyes, swollen eyelids, conjunctiva valgus, double vision or blindness, and other symptoms. X-ray examination showed thickening of the outer plate, bone destruction, such as osteoporosis. In accordance with the type of leukemia may be, the general combined with chemotherapy, many local mass may disappear in the near future. Can also increase local radiotherapy.

3. Congenital leukemia that neonatal period (less than four weeks), the incidence. The vast majority of acute myeloid leukemia. In addition to their clinical performance of the common characteristic of acute leukemia, the most prominent skin damage, even as the first symptom. For more invasive skin nodules, hard nodules, can be mobile, surface skin Changcheng blue or gray. Diameter of about 0.2 ~ 0.3 cm, more common in the head, face, ears, nose or flooding cadres, and even the surface can form ulcers. Skin damage can be expressed as papules, erythema multiforme, bleeding spots, eczema-like herpes or damage. Anemia often not obvious at birth, but soon after birth hemoglobin often drop in anemia. Thrombocytopenia. WBC general increase, or even up to 1000 × 109 / L. Acute myeloid leukemia cells when the original tablets of about 10% to 80%. And other bone marrow seen the same period of leukemia. The disease can be combined other congenital malformations. Diagnosis of the disease should be and neonatal sepsis, neonatal and other hemolytic diseases like leukemia caused by reaction of identification. A shorter course of the disease in general, more than two to three months died, is not sensitive to chemotherapy drugs.

4. More hairy cell leukemia (hairy cell leukemia, HCL) formerly of leukemia reticuloendothelial hyperplasia. Morphology of the disease to appear on the specific characteristics for more hair cells. Such cells in the light microscope for the round, oval or polygon, irregular edge of the cytoplasm, or a hairy Ju Chizhuang processes, thus the name. Nuclear often irregular, often nuclear-lap 5700, occasionally nucleolus, the cytoplasm of the middle, Wright was stained blue. Scanning electron microscope that there are more cell surface scattering of slender-like hairy processes, part of a fold-cell processes. Their cell phenotype is a monoclonal antibody mature B cells, the membrane surface immunoglobulin (SmIg) for the most part positive. Acid phosphatase positive and do not be tartaric acid suppression.

Clinical manifestations in adults with chronic diseases who-Most of 70% to 90% of cases marked splenomegaly, some patients due to medical diagnosis and found splenomegaly, hepatomegaly have about half of cases, swollen lymph nodes and more not significant . Peripheral blood as often reduce the performance of whole blood cells, the majority of cases have decreased significantly tablets. Bone marrow examination is difficult, often with \ “pumped dry \” phenomenon, bone marrow biopsy to be done. Bone marrow hyperplasia reduce the performance of the tablets, increased fiber network, a moderate to extensive infiltration of the hair cells. Period of the disease rare in children, more acute disease, usually three to 10 months.

Find a diagnosis based on a typical hair cells. The disease of the current commonly used chemotherapy to perform well. Splenectomy can significantly prolong survival, and to correct blood cells decreased. Reported in the literature of α-interferon therapy have a certain effect.

5. Eosinophilic leukemia this rare disease. With the exception of the common symptoms of acute leukemia, often the heart, lung and central nervous system and other organs of the invasion symptoms. Invasive cardiac ventricular wall can occur thrombosis, endocardium, myocardial fibrosis and necrosis, the performance for congestive heart failure and abnormal electrocardiogram. Still visible drowsiness, coma, convulsions, central nervous system symptoms, such as hemiplegia. Pulmonary infiltration can be a chronic cough, difficulty in breathing, cyanosis, such as audio-lung.

Blood in the eosinophil continued to increase significantly, the majority of up to 60 percent or more, and often naive of eosinophils. Bone marrow of eosinophilia, abnormal shape, nuclear the left, there are various stages naive eosinophils, the original tablets of> 5%.

Diagnosis to be ruled out other causes of eosinophilia. The bad effects of chemotherapy.

6. Of Alkaliphilic myeloid leukemia this disease is also rare. Clinical symptoms to anemia, bleeding more prominent, liver, spleen, lymph nodes rare.

As in the blood cells of Alkaliphilic tablets increased significantly, and naive type of Alkaliphilic tablets cells. This shows that a large number in the bone marrow cells of Alkaliphilic tablets, the original tablets of cells increased, the various stages of Alkaliphilic tablets of cells increased, the the left. Coarse particles in the cytoplasm, toluidine blue or flashing blue flowers (Astia Blue) were positive, this can be neutral particles and cells of the distinction.

Diagnosis should rule out other causes of Alkaliphilic tablets of the cells increased. Chemotherapy ineffective, and often trigger DIC, and more in the short term and died of intracranial hemorrhage visceral bleeding.

Leukemia incidence of internal and external reasons

External factors is an indispensable condition for the incidence, there are three types:
1. Physics: the main radiation, UV to asbestos fibers as the representative of the dust, cadmium, asphalt as the representative of various harmful substances. Long-term exposure to these substances than the disease the opportunity to contact high-three to 10 times. Such as the atomic bomb in Hiroshima, Japan, the former Soviet Union nuclear power plant accidents have caused a considerable number of leukemia patients.
2. Chemical: leukemia and 80 percent of the pollution.
3. Biological: Lord caused by viruses and bacteria.
More than external factors, mainly due to the following five.
1. Genetic: family history of leukemia and for how high, sometimes higher than the general population 3-4 times.
2. Spirit: the spirit and the longer suppressed and depressed on.
3. Immune: weakened immunity are prone to malfunction or disease.
4. Bad habits: smoking, including alcohol, the partial eclipse and unscientific, such as cooking.
5. Nutrition: Recipes of the vitamins, minerals and protein, fat, sugar, cellulose, such as lack or loss of balance, and so can cause disorder in the environment.

Mixed leukemia

Mixed nature of leukemia is a group of a significant difference between the acute leukemia, according to its morphology P, / \ B diagnostic criteria difficult to categorize. Using monoclonal antibodies and molecular genetics techniques can be mixed acetabular Xuebing divided into two types:
(1) Two-table-type door Xuebing cells at the same time expressed tablets, leaching of the two cell antigen;
(2) Double-series with two groups of patients with leukemia cells, respectively, and the expression of lymphatic tablets of antigen. If the first for a series of cells, with or without treatment into another series of cells, known as converters;
(3) is very rare double-cloning, genetics methods that use cell leukemia cells for cloning two completely different composition. Mixed determine the type of leukemia in the formulation of the leukemia treatment and prognosis, is of great significance.

More hairy cell leukemia

This disease of a special type of B chronic lymphocytic leukemia. There are patients with anaemia, fever, splenomegaly, blood cells are often reduced. Diagnosis of the disease is the main basis for the peripheral blood or bone marrow to see more of the characteristics of hair cells. Cytoplasm surrounding irregular, or a pseudo-foot-Ju Chizhuang processes, sometimes for long hair-out. The difference microscope and scanning electron microscope to identify hair cells is an important means. Acid phosphatase staining was positive and without inhibition of L-tartaric acid. Immune type characterized by CD25, CD11 was strongly positive. Splenectomy for the treatment of first choice, high-dose interferon and adenovirus, such as Ning dehydrogenase inhibitor for the treatment of the disease have good effect. To consider a conditional-inch bone marrow transplant.

Allergic physical risk leukemia

How dangerous allergic » Swedish Karolinska Medical College of the latest research shows that allergies may result in adults suffering from leukemia.

Karolinska Medical School scientists spent 31 of the time, follow-up survey of the 16,539 pairs of adult twins after suffering from cancer, found that in children had measles and other allergic symptoms in people suffering from leukemia than the probability Higher than many other people.

The researchers analyzed after that allergies cause leukemia because the allergic environment on the body’s immune system to stimulate the long-term and chronic damage induced by the activity of the cancer cells, thus increasing the allergic patients suffering from the possibility of leukemia.

This discovery is also available in an important sense, that is to overthrow the modern medicine “can monitor the immune function,” the thesis. It shows that the environment on human immunity has a profound impact. Karolinska Medical School scientists recommended that people should pay attention to their living environment, especially those who are allergic to the people, once found strange on the timely medical treatment to avoid inadvertently bring more serious diseases.

Leukemia

Leukemia is a malignant disease of the hematopoietic tissue, commonly known as “blood”, is characterized by a certain type of leukemia cells in bone marrow or other blood in the tumor proliferation and infiltration can be in various organs, tissues, organs so that all the damage , To produce the signs and symptoms. Clinical often anaemia, fever, infection, bleeding and liver, spleen, lymph nodes, such as different levels of enlargement. In the bone marrow and peripheral blood cells may appear naive.

Leukemia will be directly transmitted?

Leukemia is a human hematopoietic system cancer, often referred to as leukemia. We know that bone marrow is the body’s blood factory, with many blood cells, hematopoietic cells from the proliferation and development into the WBC, such as red blood cells and platelets. The body’s blood cells in cancer under the effect of cancer, causing a large number of naive cells broad and does not control the proliferation, seen in the bone marrow and other organs, also entered the peripheral blood, on the formation of leukemia. Patients showed anemia, fever, hemorrhage, infection and other symptoms. Leukemia is not directly transmitted, the only genetic susceptibility to leukemia, rather than leukemia itself. Another information that the twin children, one was suffering from acute leukemia, another opportunity to illness than the normal high 25 percent.