Leishmaniasis (Kala - azar) also known as visceral leishmaniasis (Visceral Leishmaniasis), is caused by Du Leishmania, Bai Ling as the spread of chronic endemic infectious diseases. To long-term clinical irregular fever, swelling of the spleen, suffering from weight loss, anemia, leukopenia and characterized by increased plasma globulin.
[Pathogen]
Du leishmaniasis parasite (Leishmania donovani) is a parasite Trypanosoma Kelishenman, the parasite cells lamblia. And the four types of human pathogens is in the form of Leishmania there is no difference in disease and immunological characteristics are different, tropical Leishmania and Mexico Leishmania cause the skin disease leishmaniasis ( “Oriental boil”);nasopharyngeal mucosa leishmaniasis parasite caused the disease; Du Leishmania parasites in the main network offal - endothelial system, from kala-azar.
Du Leishmania before the flagellin-life history of flagella and no body. The former is seen at Bai Ling digestive tract, in the 22 ~ 25 ℃ medium, a spindle, a front-end free flagellum, and the length of its body length is similar, about 11 × 16 μ m. Li Du and the body found in mammalian cells, tissue culture at 37 ℃, was egg-shaped park, the size of about 4.4 × 2.8 μ m.
When the female Bai Ling bites of infected animals and, to inhalation of blood Li Du Bai Ling stomach, 2 to 3 ripe for the future development of the former flagellum, parallel rapid propagation separatist dichotomy, one week ago after gathering a large number of flagella Bailing on the oral and mouth parts, when it bites human or animal body before flagella that penetrated the body, the flagella of falling into a flagellum (Lidu body).
[Epidemiological]
(A) source of infection patients and Bingquan as the main source of infection. North east of Henan and northern Anhui in the plain areas of the main mountain plateau to the northwest mainly Bingquan.
(B) transmission Bai Ling of China is China’s major mass media kala-azar, transmitted mainly through bites Bai Ling, the dual may be damaged skin and mucous membranes, placenta or blood transfusion.
(C) susceptibility to the crowd generally susceptible population, the disease after lasting immunity. Healthy people can have different levels of natural immunity.
(D) popular features of a wider distribution of the disease, China, India, Bangladesh, West Asia, the Mediterranean region, East Africa and Latin America have found. North of the Yangtze River of China’s popular 17 provinces. Because of the slow onset, no significant seasonal incidence. 10-year-old children within Most of male than female. The more rural than urban.
[Pathogenesis and pathological changes]
When Bai Ling bites affected people, it will be before the flagella of subcutaneous injection, a small number of neutrophils slope was bad, most of the reticuloendothelial system macrophages and swallowed up by breeding them in, hyperplasia, with the flow To the body, the destruction of macrophages, the other being a single nuclear swallowed up by macrophages, so repeatedly, leading to the body-nuclear proliferation macrophages to the liver, spleen, bone marrow and lymph node-based damage. Cell proliferation and the secondary is the obstruction of congestive liver and spleen, lymph nodes of the basic reasons. Because of hypersplenism and cell toxicity caused by autoimmune hemolytic allergy, can cause decreased blood cells, platelets significantly lower patients prone epistaxis, gingival bleeding. Since tablets of immune cells and reduce the activity of the cells, due to the lower immune function and easy to cause secondary infection. Reticuloendothelial system because of the proliferation of plasma cells increased substantially, due to increased plasma globulin, coupled with liver damage reduction of albumin, resulting in the ratio of plasma inverted egg white ball. If kidney damage can produce proteinuria.
Major diseases found in the following organs: the spleen significant swelling, weight up to 4-5 kg, capsule thickening and proliferation of macrophages containing a large number of Lidu, the plasma cell proliferation, the spleen may be due to blocked blood flow in congestive small artery Compression, a splenic infarction and spleen Gong hyperthyroidism. Late because of fibrous tissue proliferation swollen spleen hardens. Gall liver were mild to moderate swelling, thickening capsule, the District, sinusoidal, and Kupffer cells, Li Du of a large number of plasma cells and lymphocytes. Gan Xiaoye Centre liver cells and shrink under pressure, liver cells around the muddy swollen, or because of ischemia in fatty liver degeneration, or connective tissue proliferation lead to cirrhosis. Hyperplasia Chenganhongse extreme bone marrow, fat tissue significantly reduced macrophage proliferation obviously, that a large number Lidu; David tablets in the abnormal cells increased, and the late David tablets tablets of the cells, eosinophils decreased significantly; Nucleated red blood cells increase megakaryocyte normal or reduced, and significant reduction in platelets. Swollen lymph nodes, the cortex, medulla and can be found in the sinus with Li Du of macrophages, plasma cells increased. In addition, the tonsils, lung, kidney, pancreas, testes, and other organizations also macrophage proliferation, and to find Li Du of guitar. Glomerular basement membrane on the blood vessels that immune complex (IgG, M and C3) deposition, tips can be caused by immune complex nephropathy.
[Clinical]
The incubation period vary in length and an average of three to six months (10 to 9).
Early symptoms of fever, slow onset, and symptoms rather than the typical light, long-term irregular fever, about 1 / 2 to 1 / 3 cases were bimodal heat, a day temperature has increased 2 (movements of more than 1 ℃ ). Other heat can be similar to typhoid, tuberculosis, malaria or heat wave (that is, Bruton’s disease bacilli). Early fever for three to five more weeks dissipated, a few weeks after the rise again, with intermittent recurrence of such alternative, sustainable more than one year. Can be associated with chills, fever, night sweats loss of appetite, fatigue, dizziness and other symptoms. Although the fever continued over a long time, but still persist in the general labor, its characteristics.
Disease after 3 to June typical symptoms gradually clear, long-term irregular fever, fatigue, Nacha, suffering from weight loss and coughing. Anemia can hemorrhage palpitations, shortness of breath and anemia Maung, severe heart can be expanded and heart failure. Due to factors such as small board will have to reduce epistaxis, bleeding gums, and other bleeding tendencies. Enlargement of the spleen was carried out, since the disease two or three weeks to reach techniques, such as after the swollen spleen extended period of clear and gradually hardens, six months can-umbilical, while up to the pelvic, if the spleen, suppository or cold Bleeding, spleen may cause pain and tenderness, and friction can sometimes hear the sound. Later enlarged liver, spleen swollen than light, occasionally jaundice and ascites, lymph nodes were mild to moderate swelling, no tenderness.
Late patients (incidence 1 to 2 years) due to chronic malnutrition fever, extreme weight loss, resulting in children with developmental disorders. After a skin condition aggravated pigmentation, even to cirrhosis. Gong also because of hyperthyroidism spleen, reducing resistance, often complicated by pneumonia, tablets cell deficiency, such as sepsis.
In addition, lymph nodes and skin type of kala-azar, can be found in the lesions of Lidu.
[Complications]
(A) easy to secondary bacterial infections with lung inflammation, bacillary dysentery, gingival fester, Zouma Malnutrition, and so on.
(B) of agranulocytosis for the performance of high fever, extreme exhaustion, oropharyngeal ulcers and necrosis, regional lymph node swelling and blood cells as tablets in a significant reduction, or even disappear.
[Diagnosis and differential diagnosis]
(A) diagnosis
1. Epidemiological data pandemic stay or living history, Bai Ling activities for the season.
2. Clinical performance of the slow onset, long-term, repeated irregular fever, swelling of the spleen, anemia, weight loss, such as leukocyte reduction, and relatively less serious symptoms of systemic poisoning.
3. Laboratory
(1) reduce blood cells, WBC and more in the 1.5 ~ 3.0 × 108 / L, or even the lack of neutrophil; was moderate anemia, thrombocytopenia.
(2) plasma globulin was significantly higher, globulin precipitation test (water test), aldehyde coagulation tests, tests of antimony Duocheng positive albumin reduction, A / G can be inverted.
(3) serum antibodies specific antigen test positive will help diagnosis. Bone marrow, lymph nodes or spleen, liver pinning smears, found in Lidu or puncture See previous investigations of training can be confirmed in flagellum.
(4) in the treatment of diagnosis: antimony sodium gluconate available for trial, if the effect of significantly contribute to the disease diagnosis.
(B) the differential diagnosis
Application of this disease, tuberculosis, typhoid fever, malaria, Bruton’s disease bacilli, white hyperlipidemia and malignant cell disease, Hodgkin’s disease, schistosomiasis and other causes of chronic liver cirrhosis caused by, the evil of acute bacterial disease of the heart, such as periostitis Identification.
[Prognosis]
The prognosis depends on early diagnosis and early treatment. If not treated, the patient can be two or three years because of the incidence and deaths. Since the use of sodium gluconate antimony, the mortality reduction, the cure rate was 95%. A few may relapse. There are complications and poor prognosis.
[Treatment]
(A) General symptomatic treatment rest and nutrition, and complications to give blood for transfusion or tablets of cells, such as anti-infection.
(B) the preferred treatment of pathogenic antimony sodium gluconate, the total dose of adult <90 ~ 130 mg / kg, children 150 ~ 200 mg / kg, at 6, a day, or intravenous injection. Rapid and significant effect, fewer side effects. Disease-risk patients with anti-Ganji or want to switch to three weeks or therapy. Antimony of the invalid or taboo to the following non-optional antimony drugs:
1. Pentane acetamiprid (pentamidine): dose of 4 mg / kg / times, preparation of a fresh injection of 10% solution, daily, or between 1 and 10 to 15 for a course of treatment. Cure rate of around 70%.
2. The amphotericin B: antimony and pentane Acetamiprid effects of poor Shi Kejia with a daily dose from 0.1 mg / kg, gradually increased to 1.0 mg / kg, or between the intravenous drip ease, the total dose of 2.0 adults . The drug toxic to the kidneys and other organs, and to use adrenal cortex hormones, if there should be withdrawal proteinuria.
(C) splenectomy Splenectomy or spleen work with hyperthyroidism, or a variety of treatment should be considered invalid splenectomy. After treatment for pathogens, one year after treatment without recurrence, as cured.
[Prevention]
Is the main preventive measures and treatment of patients with killing Bingquan. At the same time the spraying season Bailing activities DDV, trichlorfon and other drugs to kill Bai Ling and to prevent breeding.